Description: The use of fundamental techniques in molecular biology and molecular genetics are illustrated using examples from the classic and current literature. Selected topics include eukaryotic gene cloning, transgenic animals, rational drug design, DNA replication and cell cycle regulation.
Description: This course will explore how metabolic pathways are currently being re-engineered in microorganisms to produce drugs that are otherwise difficult to manufacture. We will also investigate how drug targets are being identified using newly developed chemical genetic screening methods. The impact of both approaches on medicine will be evaluated.
Description: Topics to be considered at an advanced level will include: translation, folding and assembly, targeting, turnover, structure and motifs.
Description: The course will cover applied aspects of protein chemistry in biotechnology and protein design. Topics covered will include applications of modern analytical and biophysical techniques used in proteomics and related biochemical analyses, protein structure design, and antibody engineering.
Description: Key cellular pathways that are frequently subverted in tumour cells leading to neoplasia will be discussed, as well as mechanisms by which environmental factors affect tumour development. Cancer models and molecular therapies will also be considered.
Description: The translation of cancer research discoveries into clinical practice, emphasizing critical thinking, research design, evaluation of data from the literature and ethics. Students will engage with community partners associated with cancer research, patient support and care, and will work on a team project relevant to the partners’ needs.
Description: In this course, knowledge of molecular biology, biochemistry, cytogenetics, and genomics is applied to the understanding of human genetic diseases. Topics of current interest are used as examples to study the transition from mutations to clinical disorders.
Description: The major laboratory course for the Honors Specialization in Biochemistry and Honors Specialization modules combined with Biochemistry. Lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).